Impacts of Fc[gamma]RIIB and Fc[gamma]RIIIA gene polymorphisms on systemic lupus erythematous disease activity index

Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fc[gamma] receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleoti...

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Bibliographic Details
Published inBMC research notes Vol. 14; no. 1
Main Authors Karimifar, Mansoor, Akbari, Khosro, ArefNezhad, Reza, Fathi, Farshid, Moosaeepour, Mohammad, Motedayyen, Hossein
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 18.12.2021
Subjects
Diagnosis
Genetic aspects
Genetic susceptibility
Health aspects
Risk factors
Single nucleotide polymorphisms
Systemic lupus erythematosus
Iran
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Summary:Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fc[gamma] receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within Fc[gamma]RIIB and Fc[gamma]RIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population. Our findings indicated TT and GG genotypes were the common genotypes of Fc[gamma]RIIB and Fc[gamma]RIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of Fc[gamma]RIIB and Fc[gamma]RIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of Fc[gamma]RIIB and Fc[gamma]RIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P < 0.001-0.5).
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-021-05868-2