Dietary Effect of Silk Protein on Ceramide Synthesis and the Expression of Ceramide Metabolic Enzymes in the Epidermis of NC/Nga Mice
Ceramide rich intercellular lipid lamellae are thought to be particularly important in maintaining the structural integrity of epidermal barrier. Ceramide is synthesized de novo by serine palmitoyltransferase (SPT) phospholipid intermediates, serine and palmitic acid persist within the stratum corne...
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Published in | Han'guk Sikp'um Yŏngyang Kwahakhoe chi Vol. 36; no. 5 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
01.05.2007
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Subjects | |
Online Access | Get more information |
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Summary: | Ceramide rich intercellular lipid lamellae are thought to be particularly important in maintaining the structural integrity of epidermal barrier. Ceramide is synthesized de novo by serine palmitoyltransferase (SPT) phospholipid intermediates, serine and palmitic acid persist within the stratum corneum. The ceramide which is synthesized is degraded with fatty acid and sphingosine by degradative enzyme ceramidase. The depletion of ceramide in stratum corneum was reported in the atopic dermatitis. As an effort to search for the dietary source for improving the level of ceramide in epidermis, the dietary effects of various-typed silk protein were compared. |
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Bibliography: | 2007003255 Q01 |
ISSN: | 1226-3311 |
DOI: | 10.3746/jkfn.2007.36.5.554 |