Effects of Alginate on the Production of Type Ⅱ Collagen in Chondrocytes and on the Osteoarthritic Model of White Rabbits

This study was carried out to examine the in vitro effects of alginate (LVA) which is low viscosity alginic acid, on collagen type Ⅱ synthesis of chondrocytes and the in vivo effect, orally administered, on cartilage degradation. Rabbit articular chondrocytes were cultured in 35 mm dishes and then L...

Full description

Saved in:
Bibliographic Details
Published inKorean Journal of Pharmacognosy Vol. 38; no. 2
Main Authors Kang, H.S. (Chonnam National University, Gwangju, Republic of Korea), Kim, G.Y. (Chonnam National University, Gwangju, Republic of Korea), Jung, I. (Chonnam National University, Gwangju, Republic of Korea), Oh, S.D. (Chonnam National University, Gwangju, Republic of Korea), Kim, C.H. (Chonnam National University, Gwangju, Republic of Korea), Shim, B.S. (Chonnam National University, Gwangju, Republic of Korea), Park, K.H. (Chonnam National University, Gwangju, Republic of Korea), Oh, S.J. (Chonnam National University, Gwangju, Republic of Korea), E-mail: sjoh555@hanmail.net
Format Journal Article
LanguageKorean
Published 01.06.2007
Subjects
ALGINATE
ALGINATES
ALGINATOS
ENFERMEDADES DE LAS ARTICULACIONES
JOINT DISEASES
MALADIE DES ARTICULATIONS
Online AccessGet more information

Cover

More Information
Summary:This study was carried out to examine the in vitro effects of alginate (LVA) which is low viscosity alginic acid, on collagen type Ⅱ synthesis of chondrocytes and the in vivo effect, orally administered, on cartilage degradation. Rabbit articular chondrocytes were cultured in 35 mm dishes and then LVA was treated. The effects of LVA of various viscosity (86.5 cP(LVA1), 45.4 cP(LVA2), 21.2 cP(LVA3) and 9.6 cP(LVA4)) and various concentration (50, 100, 200 ㎍/ml of LVA4) on chondrocytes were determined by western blotting assay for the detection of collagen type Ⅱ production.
Bibliography:2007003460
F60
ISSN:0253-3073