Effects of Angelica keiskei Koidzumi and Turmeric Extract Supplementation on Serum Lipid Parameters in Hypercholesterolemic Diet or P-407-Induced Hyperlipidemic Rats

• Published in: Han'guk Sikp'um Yŏngyang Kwahakhoe chi Vol. 37; no. 6
• Main Authors: Kim, T.H. (DnP Natural Product Research Cooperation, Republic of Korea), Son, Y.K. (DnP Natural Product Research Cooperation, Republic of Korea), Hwang, K.H. (Konkuk University, Chungju, Republic of Korea), Kim, M.H. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: mhkim1129@kangwon.ac.kr
• Format: Journal Article
• Language: Korean
• Published: 01.06.2008
• Subjects: Angelica keiskei Koidzumi; CURCUMA (EPICE); CURCUMA (ESPECIA); hyperlipidemic rat; TURMERIC
• ISSN: 1226-3311
• DOI: 10.3746/jkfn.2008.37.6.708

The effects of administration alone or mixed of Angelica keiskei and turmeric extract on blood lipids were evaluated in hypercholesterolemic diet or P-407-induced hyperlipidemic rats. In the study 1, female Sprague-Dawley rats weighing 160-180 g were divided into each groups and fed high cholesterol diets for 8 weeks. Experimental groups were administered with following diets: basal diet (Normal), high cholesterol diets (1% cholesterol). We did the oral administration for evaluation in experimental groups: C (vehicle), A (angelica extract), T (turmeric extract), AT (angelica extract, turmeric extract/ 1:1 complex). The concentrations of serum total cholesterol, and LDL-cholesterol were decreased by 6.8%, 9.8% in A group, by 22.1%, 28.8% in C group and by 28.2%, 35.6% in AT group, compared to the C group, respectively. HDL-cholesterol levels were not different among the experimental groups. In the study 2, we induced the hypertriglyceridemia in rats by intraperitoneal injection of P-407 (0.5 g/㎏) once per three days. From the next day after P-407 injection beginning, we did the oral administration as the study 1. Angelica keiskei extract, turmeric extract and complex extract decreased serum triglyceride by 17.2%, 19.7% and 48.3%, respectively. These results suggested that Angelica keiskei and turmeric extract complex might have synergistic effect in lowering total cholesterol, LDL-cholesterol and triglyceride in hyperlipidemic rats.