Inhibitory Effects of Natural Products against NFAT (nuclear factor of activated T cells) Transcription Factor

The nuclear factor of activated T cells (NFAT) protein induce transcription of cytokine genes required for T-cell activation, including the IL-2 gene. Activation of NFAT normally plays a significant role in inducing immune response. However, excessive activation provokes immunopathological reactions...

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Published inKorean Journal of Pharmacognasy Vol. 34; no. 2
Main Authors Lee, I.S, Nguyen Tien Dat, Cai, X.F, Shen, G.H, Kim, Y.H. (Chungnam National University, Daejeon, Republic of Korea)
Format Journal Article
LanguageKorean
Published 01.06.2003
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Summary:The nuclear factor of activated T cells (NFAT) protein induce transcription of cytokine genes required for T-cell activation, including the IL-2 gene. Activation of NFAT normally plays a significant role in inducing immune response. However, excessive activation provokes immunopathological reactions including autoimmunity, transplant rejection and inflammation. Thus, several natural products were screened on the inhibitory activity against the NFAT transcription factor. Among them, Euonymus sieboldiana showed strong inhibitory activity against the NFAT transcription factor without affecting cell viability.
Bibliography:F50
2004004752
ISSN:0253-3073