Failure of 3-methylindole to contract the bovine pulmonary vein or to release mediators of anaphylaxis from the bovine lung in vitro

Strips of smooth muscle from the pulmonary vein, pulmonary artery, trachea and bronchus of calves were incubated in an organ bath with 3-methylindole (3MI) and 3-methyloxindole (3MOI). 3MI and 3MOI (5-640 micrograms/ml) did not cause contraction of any of the isolated smooth muscle preparations. No...

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Bibliographic Details
Published inVeterinary research communications Vol. 5; no. 4; pp. 355 - 361
Main Authors Hanafy, M.S.M, Bogan, J.A
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.1982
Subjects
animal health
Animals
Bronchi
Cattle
Histamine Release - drug effects
In Vitro Techniques
Indoles - pharmacology
Lung - drug effects
Lung - metabolism
Muscle Contraction - drug effects
Muscle Relaxation - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth, Vascular - drug effects
p-Methoxy-N-methylphenethylamine - pharmacology
Pulmonary Artery
Pulmonary Veins
Skatole - pharmacology
SRS-A - metabolism
Trachea
veterinary medicine
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Summary:Strips of smooth muscle from the pulmonary vein, pulmonary artery, trachea and bronchus of calves were incubated in an organ bath with 3-methylindole (3MI) and 3-methyloxindole (3MOI). 3MI and 3MOI (5-640 micrograms/ml) did not cause contraction of any of the isolated smooth muscle preparations. No evidence for the release of mediators of anaphylaxis was obtained when chopped bovine lung preparations were incubated with 3MI (20 micrograms/ml) and 3MOI (25 micrograms/ml). Results of the present work diminish the possibility that the pneumotoxic effect of 3MI is due to a primary hydrodynamic imbalance across the alveolocapillary membrane resulting in excess filtration over reabsorption.
ISSN:0165-7380
1573-7446