The Anti- and Pro-oxidative Effects of Orally Administered Flavonoids in Normal Rats

The present study was designed to investigate the effects of genistein, daidzein, and quercetin on the antioxidative systems of normal rats. Male Sprague-Dawley rats were divided randomly into seven groups and treated with flavonoids at either 2 or 20 ㎎/day or through vehicle for four weeks. Lipid p...

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Bibliographic Details
Published inNutritional sciences Vol. 7; no. 3
Main Authors Choi, E.J. (National Cancer Center, Iisan, Republic of Korea), Chee, K.M. (Korea University, Seoul, Republic of Korea), Choi, M.Y. (Sanji University, Wonju, Republic of Korea)
Format Journal Article
LanguageEnglish
Published 01.08.2004
Subjects
ANTIOXIDANTES
ANTIOXIDANTS
ANTIOXYDANT
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Glutathione-related mechanism
LIPID PEROXIDATION
PEROXIDACION LIPIDICA
PEROXYDATION DES LIPIDES
Prooxidant
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Summary:The present study was designed to investigate the effects of genistein, daidzein, and quercetin on the antioxidative systems of normal rats. Male Sprague-Dawley rats were divided randomly into seven groups and treated with flavonoids at either 2 or 20 ㎎/day or through vehicle for four weeks. Lipid peroxidation in the liver was inhibited significantly following administration of quercetin. Genistein and daidzein did not have significant effects except in rats treated with 20㎎ daidzein/day. Genistein and daidzein treatment did not affect the content of α-tocopherol in the serum and liver, while quercetin caused a slight increase.
Bibliography:S01
2005010952
ISSN:1229-232X