High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects

• Published in: Diabetes care Vol. 34; no. 9; pp. 2113 - 2115
• Main Authors: Chen, Cheng, Cheung, Bernard M.Y, Tso, Annette W.K, Wang, Yudong, Law, Lawrence S.C, Ong, Kwok Leung, Wat, Nelson M.S, Xu, Aimin, Lam, Karen S.L
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2011
• Subjects: Analysis; Asian Continental Ancestry Group; Asian People; Biological and medical sciences; blood; blood glucose; China; Development and progression; Dextrose; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme-linked immunosorbent assay; Enzymes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; fasting; Fibroblast Growth Factors; Fibroblast Growth Factors - blood; fibroblasts; Glucose; glucose tolerance; Homeostasis; Humans; Insulin resistance; Liver diseases; Logistic Models; Medical sciences; Metabolic diseases; Metabolic disorders; Miscellaneous; noninsulin-dependent diabetes mellitus; Nutrition; Obesity; odds ratio; Original Research; Plasma; Prediabetic state; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; regression analysis; risk factors; Studies; Triglycerides; Type 2 diabetes; waist circumference; Asia; China; Hong Kong, China; Endocrinopathy; Type 2 diabetes; Human; Fibroblast growth factor; Asiatic; Nutrition; Metabolic diseases; Statistical study; Blood plasma; Prospective; Chinese; Predictive factor; Endocrinology; Public health
• ISSN: 0149-5992; 1935-5548; 1935-5548
• DOI: 10.2337/dc11-0294

OBJECTIVE: To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS: Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with diabetes development over 5.4 years was analyzed using multiple logistic regression. RESULTS: At baseline, plasma levels of FGF21 increased progressively with worsening dysglycemia from normal glucose tolerance, through prediabetes, to diabetes (global trend, P < 0.001). Of 1,292 subjects without diabetes at baseline, a high baseline FGF21 level was a strong independent predictor for diabetes development (odds ratio 1.792; P < 0.01), together with waist circumference and fasting plasma glucose levels. CONCLUSIONS: Plasma FGF21 levels were significantly increased in subjects with prediabetes and diabetes and predicted the development of diabetes in humans.