Adipocytokines and Insulin Resistance: The possible role of lipocalin-2, retinol binding protein-4, and adiponectin

• Published in: Diabetes care Vol. 32; no. 11; pp. S362 - S367
• Main Authors: Esteve, Eduardo, Ricart, Wifredo, Fernández-Real, José Manuel
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2009
• Subjects: Acute-Phase Proteins - genetics; Acute-Phase Proteins - metabolism; Adipokines - genetics; Adiponectin - deficiency; Adiponectin - genetics; Adipose Tissue - metabolism; Animals; Binding proteins; Cardiovascular disease; Cardiovascular diseases; Chemical properties; Chromosomes, Human, Pair 10; Colony-stimulating factors (Physiology); Cytokines - genetics; Diabetes; Disease Models, Animal; Glucose Intolerance - genetics; Humans; Hypoglycemic agents; Insulin; Insulin resistance; Insulin Resistance - genetics; Lipocalin-2; Lipocalins - genetics; Lipocalins - metabolism; Macrophages; Mice; Mice, Knockout; Obesity and Lipids; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Peptide hormones; Protein binding; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Retinoids; Retinol-Binding Proteins, Plasma - genetics; RNA, Messenger - genetics; Type 2 diabetes
• ISSN: 0149-5992; 1935-5548; 1935-5548
• DOI: 10.2337/dc09-S340

Conversely, LCN2 has recently been claimed to display anti-inflammatory effects, so that increased LCN2 levels in obesity and insulin resistance may constitute a protective mechanism against inflammation (10). [...] LCN2 upregulated peroxisome proliferatoractivated receptor (PPAR)-γ and its target genes, adiponectin, leptin, fatty acid synthase, and lipoprotein lipase in adipocytes.