Serum Amyloid A, C-Reactive Protein, and Retinal Microvascular Changes in Hypertensive Diabetic and Nondiabetic Individuals: An Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

• Published in: Diabetes care Vol. 32; no. 6; pp. 1098 - 1100
• Main Authors: Stettler, Christoph, Witt, Nicholas, Tapp, Robyn J, Thom, Simon, Allemann, Sabin, Tillin, Therese, Stanton, Alice, O'Brien, Eoin, Poulter, Neil, Gallimore, J. Ruth, Hughes, Alun D, Chaturvedi, Nish
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2009
• Subjects: Analysis; Biological and medical sciences; Biomedical research; Blood pressure; C-reactive protein; C-Reactive Protein - metabolism; Cardiac patients; Cardiovascular disease; Clinical outcomes; Cross-Sectional Studies; Diabetes; Diabetes Complications - epidemiology; Diabetes Complications - pathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Europe - epidemiology; Humans; Hypertension; Hypertension - complications; Hypertension - epidemiology; Hypertension - pathology; Medical research; Medical sciences; Metabolic diseases; Microcirculation - physiology; Miscellaneous; Original Research; Proteins; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Retinal Vessels - pathology; Risk factors; Serum Amyloid A Protein - analysis; Studies; Type 2 diabetes; United Kingdom - epidemiology; England; United Kingdom; Great Britain; Scandinavia; Europe; Endocrinopathy; Heart; Human; Hypertension; Prognosis; Diabetes mellitus; Cardiovascular disease; Metabolic diseases; Retina; Change; Serum protein; Eye; Visual system; Microcirculation; Serum amyloid protein SAA; Acute phase protein; Clinical trial; Evolution; Circulatory system; C reactive protein; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc08-2137

OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes. RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields. RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (Ptrend= 0.028) but negatively in diabetic patients (Ptrend= 0.005). The difference was unlikely to be a chance finding (P = 0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P = 0.05 for interaction). Associations were less pronounced for CRP and retinal parameters. CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals.