Changes in immunomodulatory activity of human mononuclear cells after cultivation with leaf decoctions from the genus Ligustrum L

• Published in: Phytotherapy research Vol. 13; no. 8; pp. 692 - 695
• Main Authors: Baronikova, S, Nagy, M, Grancai, D
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.1999; Wiley
• Subjects: Adjuvants, Immunologic - pharmacology; anticomplementary activity; antifungal properties; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; complement activation; Complement Activation - drug effects; Complement Activation - physiology; Drugs, Chinese Herbal - pharmacology; General pharmacology; Humans; immunomodulators; immunomodulatory activity; leaves; Leukocytes, Mononuclear - immunology; Ligustrum; ligustrum delavayanum; Ligustrum delavayanum Hariot; Ligustrum vulgare; Ligustrum vulgare L. cv. Pyramidale; Medical sciences; Medicine, Chinese Traditional; monocytes; phagocytic activity; phagocytosis; Phagocytosis - drug effects; Phagocytosis - physiology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plants, Medicinal - chemistry; traditional medicine; Asia; China; Candida albicans; Human; Oleaceae; Pharmacognosy; Complement; Plant leaf; Decoction; In vitro; Biological activity; Medicinal plant; Fungi; Immunomodulator; Antifungal agent; Mononuclear cell; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Anticomplementary activity; Spermatophyta; Fungi Imperfecti; Ligustrum; Phagocytosis; Thallophyta
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/(SICI)1099-1573(199912)13:8<692::AID-PTR562>3.0.CO;2-1

Leaf decoctions from Ligustrum vulgare (LV) and Ligustrum delavayanum (LD) were studied for can‐­didacidal activity, phagocytic activity studied on human mononuclear cells (MO) and complement activated by the classical pathway. Candidacidal activity was studied on Candida albicans SC 1539 incubated with MO. The decoction of LD increased the candidacidal activity of MO, whereas LV did not show any effect. The phagocytic activity of MO was decreased by the decoction of LV, whereas LD did not change the activity. The phagocytic index of MO incubated with LD decoction was increased, but use of the LV decoction did not show significant changes. Decoctions from LD and LV significantly decreased the haemolytic activity of complement activated by the classical pathway (conc. 0.78 mg/mL). Copyright © 1999 John Wiley & Sons, Ltd.