Sesquiterpenoids and norsesquiterpenoids from the Formosan soft coral Lemnalia laevis

• Published in: Journal of natural products (Washington, D.C.) Vol. 68; no. 12; pp. 1749 - 1753
• Main Authors: El-Gamal, A.A.H, Chiu, E.P, Li, C.H, Cheng, S.Y, Dai, C.F, Duh, C.Y
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.12.2005; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Anthozoa - chemistry; anticarcinogenic activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; chemical structure; Chemistry, Medicinal; corals; cultured cells; cytotoxicity; Drug Screening Assays, Antitumor; General pharmacology; Humans; laevinols; laevinone; Lemnalia laevis; Leukemia P388; Life Sciences & Biomedicine; Medical sciences; Mice; Molecular Structure; neolemnane; Nephtheidae; norsesquiterpenoids; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Science & Technology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; sesquiterpenoids; spectral analysis; Taiwan; Tumor Cells, Cultured; Asia; Taiwan; OCTOCORALLIA; ALCYONACEA; BOURNEI; DITERPENE; COELENTERATA; AFRICANA; Antineoplastic agent; Ketol; P388-Leukemia; Cytotoxicity; Marine environment; Coelenterata; Sesquiterpenes; Cnidaria; Bicyclic compound; Colon; Secondary alcohol; Acylate; Tumor cell; Human; Terpenoid; Pharmacognosy; Rodentia; Animal origin; Ketone; In vitro; Naphthalene derivatives; Biological activity; Vertebrata; Mammalia; Cell line; Mouse; Animal; Epoxide; Isolation; Invertebrata; Enone; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np050326r

Eight new nornardosinane sequiterpenoids, laevinols A-H (1-8), a new neolemnane sesquiterpenoid, laevinone A (9), and the previously known 6 beta-acetyl-4 beta,5 beta-dimethyl-1(10)alpha-epoxy-2 beta-hydroxy-7-oxodecalin (10) and 11,12-dihydroxy-6,10-eremophiladiene (11) were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia laevis. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.