Phenolic Compounds from the Roots of Lindera fruticosa

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 5; pp. 853 - 855
• Main Authors: Song, M.C, Nigussie, F, Jeong, T.S, Lee, C.Y, Regassa, F, Markos, T, Baek, N.I
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.05.2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: acyl-CoA:cholesterol acyltransferase; atherogenesis; Biological and medical sciences; chemical constituents of plants; chemical structure; Chemistry, Medicinal; enzyme inhibition; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Ethiopia; General pharmacology; human health; Humans; hypercholesterolemia; Life Sciences & Biomedicine; Lindera; Lindera - chemistry; Lindera fruticosa; Lipoproteins, LDL - drug effects; low density lipoprotein; Medical sciences; medicinal plants; medicinal properties; methoxybiphenyl; methylenedioxybenzhydryl alcohol; methylenedioxybenzophenone; oxidation; Oxidation-Reduction; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; phenolic compounds; Phenols - chemistry; Phenols - isolation & purification; Phenols - pharmacology; plant extracts; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; root systems; Science & Technology; spectral analysis; Sterol O-Acyltransferase - antagonists & inhibitors; trihydroxyxanthone; Ethiopia; CHOLESTEROL ACYLTRANSFERASE; COENZYME; ATHEROSCLEROSIS; INHIBITORS; ACYL-COA; XANTHONES; SECURIDACA-INAPPENDICULATA; Benzophenone derivatives; Oxygen heterocycle; Medicinal plant; Lipoprotein LDL; Dicotyledones; Angiospermae; Bicyclic compound; Aromatic compound; Oxidation; Lauraceae; Below ground plant part; Human; Acyltransferases; Root; Enzyme; Pharmacognosy; Transferases; Enzyme inhibitor; Tricyclic compound; In vitro; Biological activity; Ketophenols; Plant origin; Phenols; Benzenic compound; Isolation; Spermatophyta; Structural analysis; Sterol O-acyltransferase
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np060048b

The phenolic compounds isolated from the roots of Lindera fruticosa included four new compounds, 2-methoxy-3,4-methylenedioxybenzophenone (1), (S)-2-methoxy-3,4-methylenedioxybenzhydryl alcohol (2), 3-hydroxy-5-methoxybiphenyl (3), and 1-methoxy-2,5,7-trihydroxyxanthone (4). Three previously identified phenolics were also identified, namely, 3,5-dimethoxybiphenyl (5), benzyl 2-hydroxy-6-methoxybenzoate (6), and 1,7-dihydroxyxanthone (7). These compounds were evaluated for their inhibitory effects on human acyl-CoA:cholesterol acyltransferase activity and on the in vitro oxidation of low-density lipoprotein.