Cytotoxic xanthones from Cudrania tricuspidata

• Published in: Journal of natural products (Washington, D.C.) Vol. 68; no. 3; pp. 456 - 458
• Main Authors: Lee, B.W, Gal, S.W, Park, K.M, Park, K.H
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.2005; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; cell lines; chemical structure; Chemistry, Medicinal; Crystallography, X-Ray; cytotoxicity; Drug Screening Assays, Antitumor; General pharmacology; Humans; Korea; Life Sciences & Biomedicine; Maclura tricuspidata; Medical sciences; Molecular Conformation; Molecular Structure; Moraceae - chemistry; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Bark - chemistry; plant extracts; Plant Sciences; Plants, Medicinal - chemistry; Science & Technology; spectral analysis; stereochemistry; Tumor Cells, Cultured; X-ray diffraction; xanthones; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Asia; China; Korea; CULTIVATED MULBERRY TREE; MORACEAE PLANTS; CUDRAXANTHONE-C; COMPONENTS; ROOT BARK; ISOPRENYLATED XANTHONES; CONSTITUENTS; FLAVONES; Antineoplastic agent; Molecular structure; Lung; Bark; Cytotoxicity; Oxygen heterocycle; Diphenols; Medicinal plant; Xanthene derivatives; Folk medicine; Dicotyledones; Angiospermae; Aromatic compound; Tumor cell; Below ground plant part; Human; Root; Pharmacognosy; Moraceae; Tricyclic compound; X ray diffraction; In vitro; Biological activity; Ketophenols; Cell line; Plant origin; Isolation; Spermatophyta; Structural analysis; Crystalline structure
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np030481a

The new isoprenylated tetrahydroxyxanthone, 2,3,6,8-tetrahydroxy-1-(3-methylbut-2-enyl)-5-(2-methylbut3-en-2-yl)-9H-xanthen-9-one (1), was isolated from the root bark of Cudrania tricuspidata together with macluraxanthone B (2) and cudraxanthone L (3), which were fully characterized by NMR spectroscopic and X-ray crystallographic analyses.