Nitrogen-containing compounds from Salvia miltiorrhiza

• Published in: Journal of natural products (Washington, D.C.) Vol. 68; no. 7; pp. 1066 - 1070
• Main Authors: Don, M.J, Shen, C.C, Lin, Y.L, Syu, W.J, Ding, Y.H, Sun, C.M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.07.2005; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: antibacterial properties; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; carbaldehyde; chemical structure; Chemistry, Medicinal; cultured cells; cytotoxicity; Drug Screening Assays, Antitumor; General pharmacology; HeLa Cells; Heterocyclic Compounds - chemistry; Heterocyclic Compounds - isolation & purification; Heterocyclic Compounds - pharmacology; human health; Humans; Life Sciences & Biomedicine; Medical sciences; medicinal plants; Molecular Structure; neosalvianen; nitrogen; Nitrogen - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; phytochemicals; plant biochemistry; plant extracts; Plant Sciences; Plants, Medicinal; Salvia miltiorrhiza; Salvia miltiorrhiza - chemistry; salviadione; salvianan; salvianen; Science & Technology; spectral analysis; stereochemistry; traditional medicine; Tumor Cells, Cultured; Asia; China; CYTOTOXICITY; TANSHINONES; Antineoplastic agent; Pentacyclic compound; Five membered ring; Nitrogen heterocycle; Liver; Cytotoxicity; Uterine cervix; Medicinal plant; Ovary; Hepatocyte; Folk medicine; Dicotyledones; Angiospermae; Aromatic compound; Tumor cell; Oxygen nitrogen heterocycle; Human; Ether; Pharmacognosy; Tetracyclic compound; Aldehyde; In vitro; Hela cell line; Biological activity; Salvia miltiorrhiza; Cell line; Labiatae; Plant origin; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0500934

Five new N-containing compounds, neosalvianen (1), salvianen (2), salvianan (3), salviadione (4), and 5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde (5), were isolated from Salvia miltiorrhiza. Their structures were mainly established by spectroscopic methods. Neosalvianen (1) and its analogues (6a, 6b) were synthesized for spectroscopic data comparison. Compounds 1, 2, 4, and 6a were evaluated for their cytotoxic activities against selected cancer cell lines. Among these components, salvianen (2) exhibited the most potent cytotoxicity with a CD50 range of 30.4-39.5 mu M against HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma), and OVCAR-3 (ovarian adenocarcinoma) cell lines in a dose-dependent manner. The cytotoxicities of the tested compounds were not specific and showed similar activities to the selected cancer cell lines.