New biologically active triterpenoid saponins from Scabiosa tschiliensis

• Published in: Journal of natural products (Washington, D.C.) Vol. 67; no. 4; pp. 604 - 613
• Main Authors: Zheng, Q, Koike, K, Han, L.K, Okuda, H, Nikaido, T
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.04.2004; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Biological and medical sciences; Chemistry, Medicinal; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; General pharmacology; Life Sciences & Biomedicine; Lipase - antagonists & inhibitors; Medical sciences; Medicine, Chinese Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid - pharmacology; Pancreas - enzymology; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plants, Medicinal - chemistry; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Science & Technology; Stereoisomerism; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Asia; Mongolia; ACETATES; ACID; DIMETHYL-SULFOXIDE; THUNB; RAT; Triacylglycerol lipase; Esterases; Disaccharide; Medicinal plant; Saponin; Folk medicine; Dicotyledones; Angiospermae; Glycoside; Trisaccharide; Terpenoid; Enzyme; Pharmacognosy; Whole plant; Glucoside; Enzyme inhibitor; In vitro; Biological activity; Carboxylic ester hydrolases; Oleanane derivatives; Dipsacaceae; Plant origin; Triterpene; Hydrolases; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0304722

Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7 9), hookerosides A, B (12, 13), and prosapogenin lb all exhibited strong inhibition of pancreatic lipase in vitro.