New biologically active triterpenoid saponins from Scabiosa tschiliensis

Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and...

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Published inJournal of natural products (Washington, D.C.) Vol. 67; no. 4; pp. 604 - 613
Main Authors Zheng, Q, Koike, K, Han, L.K, Okuda, H, Nikaido, T
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.04.2004
Amer Chemical Soc
American Society of Pharmacognosy
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Summary:Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7 9), hookerosides A, B (12, 13), and prosapogenin lb all exhibited strong inhibition of pancreatic lipase in vitro.
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np0304722