Lower Baseline Glycemia Reduces Apparent Oral Agent Glucose-Lowering Efficacy: A meta-regression analysis

A potential consequence is that the pharmaceutical industry may become reluctant to develop agents effective for glycemie treatment of individuals with early diabetes, based on a perception that studying agents under those circumstances may give the appearance of inadequate efficacy.

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Bibliographic Details
Published inDiabetes care Vol. 29; no. 9; pp. 2137 - 2139
Main Authors Bloomgarden, Zachary T, Dodis, Regina, Viscoli, Catherine M, Holmboe, Eric S, Inzucchi, Silvio E
Format Journal Article
LanguageEnglish
Published United States American Diabetes Association 01.09.2006
Subjects
Agents
Analysis
Blood Glucose - analysis
Cardiovascular diseases
Clinical trials
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Glycated Hemoglobin A - analysis
Glycemic index
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Meta-analysis
Patients
Pharmaceutical industry
Regression Analysis
Risk factors
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Summary:A potential consequence is that the pharmaceutical industry may become reluctant to develop agents effective for glycemie treatment of individuals with early diabetes, based on a perception that studying agents under those circumstances may give the appearance of inadequate efficacy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0149-5992
1935-5548
DOI:10.2337/dc06-1120