Kalanchosine Dimalate, an Anti-inflammatory Salt from Kalanchoe brasiliensis

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 5; pp. 815 - 818
• Main Authors: Costa, S.S, Souza, M. de L.M. de, Ibrahim, T, Melo, G.O. de, Almeida, A.P. de, Guette, C, Férézou, J.P, Koatz, V.L.G
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: anti-inflammatory activity; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; bioassays; Biological and medical sciences; Brazil; Chemical Sciences; chemical structure; Chemistry, Medicinal; Crassulaceae; General pharmacology; Kalanchoe; Kalanchoe - chemistry; Kalanchoe brasiliensis; kalanchosine dimalate; Life Sciences & Biomedicine; Malates - chemistry; Malates - isolation & purification; Malates - pharmacology; malic acid; Medical sciences; medicinal plants; mice; Molecular Structure; Organic chemistry; ornamental plants; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plants, Medicinal - chemistry; Science & Technology; spectral analysis; traditional medicine; Brazil; MICROBIAL PRODUCTS; ACTIVATION; TUBERACTINOMYCIN; ACID; INHIBITORS; DERIVATIVES; Intraperitoneal administration; Crassulaceae; Medicinal plant; Carboxylic acid; Dicotyledones; Angiospermae; Phytotherapy; Aminoalcohol; Aliphatic compound; Pharmacognosy; Rodentia; Antiinflammatory agent; Inflammation; Biological activity; Vertebrata; Mammalia; Treatment; Mouse; Aminoacid; Animal; Plant origin; Isolation; Above ground plant part; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np050475+

This report describes the isolation and characterization of kalanchosine dimalate (KMC), an anti-inflammatory salt from the fresh juice of the aerial parts of Kalanchoe brasiliensis. KMC comprises the new metabolite kalanchosine (1) and malic acid (2) in a 1:2 stoichiometric ratio. Kalanchosine (1), 3,6-diamino4,5-dihydroxyoctanedioic acid, is the first naturally occurring dimeric bis(gamma-hydroxy-beta-amino acid) and is at least partially responsible for the anti-inflammatory properties of K. brasiliensis.