Large granular lymphocytic leukemia in a mixed breed dog

A mixed breed dog was diagnosed with large granular lymphocytic leukemia. Immunophenotypic analysis indicated the lymphocytes were CD3+, CD8+ T cells expressing the alpha beta T cell receptor and a leukointegrin, alpha d. Chemotherapy and splenectomy resulted in an initial reduction in the lymphocyt...

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Bibliographic Details
Published inCanadian veterinary journal Vol. 40; no. 10; pp. 725 - 728
Main Authors Lau, K.W.M, Kruth, S.A, Thorn, C.E, Vernau, W, Moore, P
Format Journal Article
LanguageEnglish
Published Canada 01.10.1999
Subjects
Animals
Antineoplastic Agents - therapeutic use
case studies
Dog Diseases - pathology
Dog Diseases - therapy
Dogs
drug therapy
Female
leukemia
Leukemia, T-Cell - pathology
Leukemia, T-Cell - therapy
Leukemia, T-Cell - veterinary
splenectomy
Splenectomy - veterinary
T-lymphocytes
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Summary:A mixed breed dog was diagnosed with large granular lymphocytic leukemia. Immunophenotypic analysis indicated the lymphocytes were CD3+, CD8+ T cells expressing the alpha beta T cell receptor and a leukointegrin, alpha d. Chemotherapy and splenectomy resulted in an initial reduction in the lymphocyte count.
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ISSN:0008-5286