Diterpenes from Leucas aspera Inhibiting Prostaglandin-Induced Contractions

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 7; pp. 988 - 994
• Main Authors: Sadhu, S.K, Okuyama, E, Fujimoto, H, Ishibashi, M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.07.2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Antioxidants - pharmacology; Bangladesh; Biological and medical sciences; Biphenyl Compounds; chemical structure; Chemistry, Medicinal; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; General pharmacology; glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Guinea Pigs; ileum; Ileum - drug effects; isopimarane glycoside; Lamiaceae; Lamiaceae - chemistry; Leucas aspera; leucasperones; leucasperosides; Life Sciences & Biomedicine; Male; Medical sciences; medicinal plants; Molecular Structure; muscle contraction; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Picrates - pharmacology; Plant Sciences; Plants, Medicinal - chemistry; Prostaglandin Antagonists - chemistry; Prostaglandin Antagonists - isolation & purification; Prostaglandin Antagonists - pharmacology; prostaglandins; Science & Technology; smooth muscle; spectral analysis; Bangladesh; CHEMISTRY; ORTHOSIPHON-STAMINEUS; Ketol; Alcohol; Smooth muscle; Oxygen heterocycle; Disaccharide; Medicinal plant; Guinea pig; Antispasmodic agent; Dicotyledones; Angiospermae; Bicyclic compound; Glycoside; Inhibition; Dispirane; Acylate; Trisaccharide; Terpenoid; Pharmacognosy; Rodentia; Gut; Geometrical configuration; Tetracyclic compound; Tricyclic compound; Muscle contraction; Ketone; Ileum; In vitro; Biological activity; Vertebrata; Mammalia; Labiatae; Plant origin; Diterpene; Isolation; Spermatophyta; Enone; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np058118m

Investigation of the inhibitory fraction of Leucas aspera on prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A ( 1) and B ( 2) and leucasperols A ( 3) and B ( 4), and three new isopimarane glycosides, leucasperosides A, B, and C (5-7), together with the known compounds asperphenamate, maslinic acid, (-)- isololiolide, and linifolioside. The structures of the compounds were determined by detailed spectroscopic analysis. The configurations of 1 and 2 and the acetylated derivatives of 3 and 4 were determined by differential NOE analysis and CD data. Leucasperone A ( 1), leucasperosides A ( 5) and B ( 6), and linifolioside showed inhibition of prostaglandin-induced contractions.