Five new ocotillone-type saponins from Gynostemma pentaphyllum

• Published in: Journal of natural products (Washington, D.C.) Vol. 67; no. 7; pp. 1147 - 1151
• Main Authors: Liu, X, Ye, W, Mo, Z, Yu, B, Zhao, S, Wu, H, Che, C, Jiang, R, Mak, T.C.W, Hsiao, W.L.W
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.07.2004; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Biological and medical sciences; Chemistry, Medicinal; Crystallography, X-Ray; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; General pharmacology; Gynostemma - chemistry; Life Sciences & Biomedicine; Medical sciences; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Saponins - chemistry; Saponins - isolation & purification; Science & Technology; Asia; China; GLYCOSIDES; MAKINO; Steroid; Terpenoid; Pharmacognosy; Cucurbitaceae; Furan derivatives; Alcohol; Polycyclic compound; Oxygen heterocycle; X ray diffraction; Disaccharide; Medicinal plant; Saponin; Acetal; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Triterpene; Isolation; Above ground plant part; Spermatophyta; Glycoside; Structural analysis; Crystalline structure
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np034018+

Five new ocotillone-type saponins, gynosides A-E (1-5), along with 10 known dammarane-type saponins, were isolated from the aerial parts of Gynostemma pentaphyllum. The structures of these new compounds were determined by NMR analysis and acid hydrolysis. The structure and stereochemistry of gynoside A (1) were confirmed by X-ray crystallography.