Steroids from the roots of Nerium oleander

• Published in: Journal of natural products (Washington, D.C.) Vol. 62; no. 7; pp. 1065 - 1067
• Main Authors: Huq, M.M, Jabbar, A, Rashid, M.A, Hasan, C.M, Ito, C, Furukawa, H
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.07.1999; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Biological and medical sciences; Carbohydrate Sequence; cardenolides; chemical constituents of plants; chemical structure; Chemistry, Medicinal; General pharmacology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Molecular Sequence Data; Nerium oleander; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; roots; Science & Technology; spectral analysis; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Steroids - chemistry; Steroids - isolation & purification; Bangladesh; Asia; ODORUM; NMR; C-13-NMR; CARDENOLIDE; LEAVES; CARDIAC-GLYCOSIDES; Steroid; Cardiotonic agent; Cardenolide; Aldose; Root; Pharmacognosy; Lactone; Oxygen heterocycle; Medicinal plant; Apocynaceae; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Glycoside; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np990031b

Two new cardenolides, 3 beta-hydroxy-5 alpha-carda-14(15),20(22)-dienolide (beta-anhydroepidigitoxigenin) (1) and 3 beta-O-(D-digitalosyl)-21-hydroxy-5 beta-carda-8,14,16,20,(22)-tetraenolide (neriumogenin-A-3 beta-D-digitaloside) (2), and two known compounds, proceragenin and neridienone A (3), have been isolated from the roots of Nerium oleander. The structures of 1 and 2 were elucidated on the basis of spectral data interpretation.