Indole alkaloids from the tunicate Aplidium meridianum

• Published in: Journal of natural products (Washington, D.C.) Vol. 61; no. 9; pp. 1130 - 1132
• Main Authors: Franco, L.H. (Universidad de Buenos Aires.), Kier Joffe, E.B. de, Puricelli, L, Tatian, M, Seldes, A.M, Palermo, J.A
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.09.1998; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: ALKALOIDS; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; ANTINEOPLASTIC AGENTS; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; AQUATIC ANIMALS; Biological and medical sciences; CELL CULTURE; CELL LINES; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemistry, Medicinal; Chromatography, High Pressure Liquid; CYTOTOXIC COMPOUNDS; Drug Screening Assays, Antitumor; FALKLAND ISLANDS (MALVINAS); General pharmacology; Humans; INDOLES; INVERTEBRATES; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; MERIDIANINS; Mice; MURINE TUMOR CELL LINES; PHARMACEUTICAL PRODUCTS; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Science & Technology; SOUTH GEORGIA ISLAND; SPECTRAL ANALYSIS; SPECTROMETRY; Spectrophotometry, Ultraviolet; TOXIC SUBSTANCES; Tumor Cells, Cultured; Urochordata - metabolism; South Atlantic; Atlantic Ocean; DENDRODOA-GROSSULARIA; ANTARCTIC SPONGE; Antineoplastic agent; Nitrogen heterocycle; Pharmacognosy; Rodentia; Animal origin; Cytotoxicity; Prochordata; In vitro; Biological activity; Urochordata; Marine environment; Vertebrata; Alkaloid; Mammalia; Mouse; Animal; Established cell line; Isolation; Pyrimidine derivatives; Invertebrata; Indole derivatives; Tumor cell
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np970493u

Five new indole alkaloids, meridianins A-E (1-5), have been isolated from the tunicate Aplidium meridianum, which was collected at a depth of 100 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Compounds 2-5 showed cytotoxicity toward murine tumor cell lines.