Polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme does not affect flight ability

We describe polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme, named TnH-34. Three variants of this protein differ in their mobilities as determined by 1-D and 2-D SDS-PAGE. Meiotic mapping places the polymorphism close to, if not within, the structural gene encoding t...

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Bibliographic Details
Published inBiochemical genetics Vol. 30; no. 3/4; p. 159
Main Authors Cripps, R.M. (San Diego State University, San Diego, CA), Sparrow, J.C
Format Journal Article
LanguageEnglish
Published United States 01.04.1992
Subjects
AILE
ALAS
Animals
Chromosome Mapping
Crosses, Genetic
DROSOPHILA MELANOGASTER
Electrophoresis, Polyacrylamide Gel
Female
Flight, Animal - physiology
GENE
GENES
GENOTIPOS
GENOTYPE
Isoenzymes - genetics
LOCOMOCION
LOCOMOTION
Male
MUSCLE
Muscles - enzymology
Muscles - physiology
MUSCULOS
MUTACION
MUTATION
POLIMORFISMO BIOQUIMICO
POLIMORFISMO GENETICO
Polymorphism, Genetic
POLYMORPHISME BIOCHIMIQUE
POLYMORPHISME GENETIQUE
PROTEINAS
PROTEINE
Tropomyosin - genetics
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Summary:We describe polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme, named TnH-34. Three variants of this protein differ in their mobilities as determined by 1-D and 2-D SDS-PAGE. Meiotic mapping places the polymorphism close to, if not within, the structural gene encoding this tropomyosin isozyme. The most likely site of the mutations is within a single C-terminal exon. Flight-testing of different genotypes reveals that this variation in TnH-34 does not affect flight ability. These results suggest that some sequence variation may be tolerated in this section of the protein and correlate with the variability of this protein in different insect species
Bibliography:9195042
L50
L10
ISSN:0006-2928
1573-4927
DOI:10.1007/BF02399706