Induced latency in pseudorabies vaccinated pigs

A latent pseudorabies virus infection was established in pigs despite vaccination with a modified-live pseudorabies virus vaccine. Although the vaccinated pigs developed high concentrations of antibody, virus was recovered from the tonsils and lungs of pigs treated with dexamethasone three months af...

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Bibliographic Details
Published inCanadian journal of comparative medicine Vol. 45; no. 1; pp. 56 - 59
Main Authors Mock, R.E, Crandell, R.A, Mesfin, G.M
Format Journal Article
LanguageEnglish
Published Canada 1981
Subjects
animal diseases
animal health
Animals
Dexamethasone - pharmacology
Female
Herpesvirus 1, Suid - isolation & purification
Male
Palatine Tonsil - microbiology
Pseudorabies - etiology
Pseudorabies - immunology
Pseudorabies - microbiology
Swine - immunology
Swine Diseases - etiology
Swine Diseases - immunology
Swine Diseases - microbiology
Vaccination - veterinary
viral diseases of animals and humans
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Summary:A latent pseudorabies virus infection was established in pigs despite vaccination with a modified-live pseudorabies virus vaccine. Although the vaccinated pigs developed high concentrations of antibody, virus was recovered from the tonsils and lungs of pigs treated with dexamethasone three months after inoculation with virulent virus. These results may explain why vaccination programs have failed to eliminate the persistence and spread of virulent pseudorabies virus in infected herds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-4050