Adiponectin Decreases Postprandially Following a Heat-Processed Meal in Individuals With Type 2 Diabetes: An effect prevented by benfotiamine and cooking method

• Published in: Diabetes care Vol. 30; no. 10; pp. 2514 - 2516
• Main Authors: Stirban, Alin, Negrean, Monica, Stratmann, Bernd, Götting, Christian, Salomon, Julia, Kleesiek, Knut, Tschoepe, Diethelm
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.10.2007
• Subjects: Adiponectin - blood; Age; Analysis of Variance; Biological and medical sciences; Body Mass Index; Chelating Agents - pharmacology; Cookery; Cooking; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Diet therapy; Diet, Diabetic; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Evaluation; Female; Food Handling; Health aspects; Hot Temperature; Humans; Hyperglycemia; Hypoglycemic Agents - therapeutic use; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous; Postprandial Period; Protein hormones; Public health. Hygiene; Public health. Hygiene-occupational medicine; Studies; Thiamine - analogs & derivatives; Thiamine - pharmacology; Type 2 diabetes; Vitamin B1; Germany; Endocrinopathy; Type 2 diabetes; Human; Neurotropic; Temperature; Cooking; Methodology; Nutrition; Meal; Environmental factor; Metabolic diseases; B-Vitamins; Method; Benfotiamine; Adiponectin; Prevention; Heat; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc07-0302

RESEARCH DESIGN AND METHODS - Nineteen inpatients with type 2 diabetes (mean ± SEM age 55.2 ± 1.9 years; diabetes duration 7.3 ± 1.2 years; BMI 29.2 ± 0.8 kg/m^sup 2^; AlC 8.8 ± 0.4%; 13 male and 6 female; 4 smokers and 15 nonsmokers; 15 on oral diabetes medication alone, 2 on oral diabetes medication plus insulin, and 2 on insulin alone; 13 on angiotensin receptor blockers, 7 on hydroxymethylglutarylCoA reductase inhibitors; 6 on β-blockers; 6 on diuretics; 2 on calcium channel blockers; and 15 on aspirin) without cardiovascular history were investigated after approval of the institutional review board and obtainment of individual written consent. Blood samples were analyzed for serum glucose, cholesterol, triglycerides, LDL and HDL cholesterol (Architect CÌ8200 analyzer; Abbott Diagnostics, Wiesbaden, Germany), thiobarbituric acid reactive substances (TBARS) (Alexis Biochemicals, Gruenberg, Switzerland), serum adiponectin (R&D Systems, Wiesbaden, Germany), insulin (DPC Biermann, Bad Nauheim, Germany), and serum methylglyoxal derivatives (enzyme-linked immunosorbent assay with monoclonal anti-methylglyoxal-BSA antibody [methylglyoxaBDll; Dr. Y. AlAbed, Picower Institute, Cambridge, MA]) (26).