Determination of combined residues of metalaxyl and 2,6-dimethylaniline metabolites in urine by gas chromatography/mass spectrometry

• Published in: Journal of AOAC International Vol. 79; no. 1; p. 117
• Main Authors: Headley, J.V. (Environment Canada, Saskatoon, SK, Canada.), Maxwell, D.B, Swyngedouw, C, Purdy, J.R
• Format: Journal Article
• Language: English
• Published: England 01.01.1996
• Subjects: AGRICULTEUR; AGRICULTORES; Alanine - analogs & derivatives; Alanine - urine; ANALISIS CUANTITATIVO; ANALYSE QUANTITATIVE; Aniline Compounds - urine; CHROMATOGRAPHIE EN PHASE GAZEUSE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CROMATOGRAFIA DE GASES; ESPECTROMETRIA DE MASAS; FONGICIDE; FUNGICIDAS; Fungicides, Industrial - urine; Gas Chromatography-Mass Spectrometry - methods; Gas Chromatography-Mass Spectrometry - statistics & numerical data; Humans; MEDICION; MESURE; METABOLITE; METABOLITOS; METALAXIL; METALAXYL; Methylene Chloride; ORINA; Pesticide Residues - urine; RESIDU; RESIDUOS; SPECTROMETRIE DE MASSE; TECHNIQUE ANALYTIQUE; TECNICAS ANALITICAS; URINE
• ISSN: 1060-3271; 1944-7922

A gas chromatographic/mass spectrometric (GC/MS) method for determination of combined residues of the fungicide metalaxyl and its metabolites in urine containing the 2,6-dimethylaniline moiety is described. The method is a modification of a method of Balasubramanian and Perez for analysis of metalaxyl in vegetables. Noted modifications include replacement of steam extraction with extraction by methylene chloride and use of electron impact ionization GC/MS in the selected-ion mode. The method is linear over the range of 0.1-5 microgram 2,6-dimethylaniline/g urine and has a detection limit of 0.025 microgram/g