Cucurbitane Glycosides from the Fruits of Siraitia grosvenorii and Their Inhibitory Effects on Epstein-Barr Virus Activation

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 5; pp. 783 - 788
• Main Authors: Akihisa, T, Hayakawa, Y, Tokuda, H, Banno, N, Shimizu, N, Suzuki, T, Kimura, Y
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.05.2007; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: 11-deoxymogroside; 11-oxomogroside; 7-oxomogroside; antiviral properties; Biological and medical sciences; chemical structure; Chemistry, Medicinal; Cucurbitaceae; cucurbitane; cucurbitane triterpene; cultured cells; Epstein-Barr virus; General pharmacology; glycosides; Human herpesvirus 4; humans; Life Sciences & Biomedicine; Medical sciences; mogroside; Momordica grosvenorii; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Science & Technology; Siraitia grosvenorii; spectral analysis; triterpenoids; China; Asia; FRUCTUS MOMORDICAE; CONSTITUENTS; Steroid; Anticarcinogen; Antitumor promotor; Disaccharide; Medicinal plant; Saponin; Folk medicine; Dicotyledones; Angiospermae; Glycoside; Inhibition; Trisaccharide; Lanostane derivatives; Terpenoid; Aldose; Fruit; Pharmacognosy; Cucurbitaceae; In vitro; Biological activity; Nitric oxide donor; Plant origin; Triterpene; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np068074x

Six new cucurbitane glycosides, mogroside II B (2), 11-deoxymogroside III (4), 7-oxomogroside II E (5), 7-oxomogroside V (6), 11-oxomogroside II A(1) (7), and 11-oxomogroside IV A (8), and two known but new naturally occurring cucurbitane glycosides, mogroside II A(1) (1) and mogroside III A(2) (3), were isolated from an ethanol extract of the fruits of Siraitia grosvenorii. Upon evaluation of compounds 1-8 for inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), all compounds exhibited inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. In addition, compounds 1-8 showed weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.