Hepatoprotective Sesquiterpene Glycosides from Sarcandra glabra

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 4; pp. 616 - 620
• Main Authors: Li, Y, Zhang, D.M, Li, J.B, Yu, S.S, Luo, Y.M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.04.2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Biological and medical sciences; Chemical and Drug Induced Liver Injury - prevention & control; chemical structure; Chemistry, Medicinal; Chloranthaceae; Chloranthus; Chloranthus glaber; cultured cells; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; elemanolide; eudesmanolide; Galactosamine - pharmacology; General pharmacology; germacranolide; glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; hepatocytes; Hepatocytes - drug effects; hepatoprotective effect; Life Sciences & Biomedicine; lindenane; Magnoliopsida - chemistry; Medical sciences; medicinal plants; medicinal properties; Molecular Structure; Oriental traditional medicine; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; phytochemicals; plant extracts; Plant Sciences; Plants, Medicinal - chemistry; Rats; sarcaglaboside; Sarcandra glabra; Science & Technology; sesquiterpene aglycon; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; sesquiterpenoids; spectral analysis; stereochemistry; China; Asia; ELUCIDATION; JAPONICUS; XINJIANG; CHEMICAL-CONSTITUENTS; LACTONES; CHLORANTHUS-GLABER; CHLORANTHALACTONE-F; PLANTS; ROOTS; Rat; Hepatoprotector; Toxicity; Germacranolid; Oxygen heterocycle; Disaccharide; Medicinal plant; Prevention; Folk medicine; Dicotyledones; Sesquiterpenes; Angiospermae; Bicyclic compound; Glycoside; Galactosamine; Terpenoid; Aldose; Pharmacognosy; Whole plant; Rodentia; Chloranthaceae; Lactone; Tetracyclic compound; Tricyclic compound; In vitro; Biological activity; Vertebrata; Mammalia; Cytoprotector; Animal; Plant origin; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np050480d

Six new sesquiterpene glycosides, compounds 1-6, with eudesmanolide, elemanolide, lindenane, and germacranolide sesquiterpene aglycons, along with one known compound, chloranoside A (7), have been isolated from the whole plant of Sarcandra glabra. The structures of 1-6 were elucidated by chemical and spectroscopic methods including H-1-H-1 COSY, HMQC, HMBC, and NOESY NMR experiments. In addition, compounds 1-7 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.