Effects of dietary hyperlipidemia-hypercholesterolemia on rat erythrocytes

We report in the present work that membrane fluidity in erythrocytes from rats under alimentary hyperlipidemia-hypercholesterolemia is slightly diminished despite the fact that in these cells the cholesterol/phospholipid molar ratio is nearly 45% higher than in erythrocytes from control animals. In...

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Bibliographic Details
Published inInternational journal for vitamin and nutrition research Vol. 60; no. 4; pp. 392 - 397
Main Authors Lucio Cazana, F.J. de, Rodriguez Puyol, M, Perez-Caballero, J, Jimenez Jimenez, A, Montes Duarte, A
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Animals
cholesterol
Cholesterol - blood
diet
Diet, Atherogenic
erythrocytes
Erythrocytes - metabolism
Erythrocytes - physiology
fat percentage
high-cholesterol diets
high-fat diets
hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - metabolism
hyperlipidemia
Hyperlipidemias - blood
Hyperlipidemias - metabolism
lipid content
Male
Membrane Fluidity
Phospholipids - blood
Rats
Rats, Inbred Strains
Reticulocytes - metabolism
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Summary:We report in the present work that membrane fluidity in erythrocytes from rats under alimentary hyperlipidemia-hypercholesterolemia is slightly diminished despite the fact that in these cells the cholesterol/phospholipid molar ratio is nearly 45% higher than in erythrocytes from control animals. In addition, the erythrocyte count in the rats given the high-fat, high-cholesterol diet was normal. Only a slight reticulocytosis was observed in these animals although their erythrocytes showed a marked decrease in their ability to extrude sodium actively. A tentative explanation for these results is proposed on the basis of other findings suggesting cellular compensatory mechanisms.
ISSN:0300-9831