Studies of biological properties of the recombinants between human influenza and fowl plague viruses as related to genome composition [virulence in chickens]

Some biological properties of recombinants obtained by crossing of fowl plague and human influenza viruses were studied. The capacity of the recombinants to reproduce in chick embryo fibroblast cultures was in reverse correlation to the number of genes coding for P proteins derived from the human in...

Full description

Saved in:
Bibliographic Details
Published inActa virologica (Anglickâa verze) Vol. 26; no. 6; p. 432
Main Authors Ginzburg, V P, Markushin, S G, Ghendon, Y Z
Format Journal Article
LanguageEnglish
Published Slovakia 01.01.1982
Subjects
Animals
Cells, Cultured
Chick Embryo
Chickens
Genes, Viral
Humans
Influenza A virus - genetics
Influenza A virus - pathogenicity
Influenza A virus - physiology
Nasal Polyps - microbiology
Organ Culture Techniques
Recombination, Genetic
Temperature
Viral Plaque Assay
Virus Replication
Online AccessGet more information

Cover

More Information
Summary:Some biological properties of recombinants obtained by crossing of fowl plague and human influenza viruses were studied. The capacity of the recombinants to reproduce in chick embryo fibroblast cultures was in reverse correlation to the number of genes coding for P proteins derived from the human influenza virus. The genome composition was of importance for the expression of ts-phenotype of the recombinants in different systems. Substitution of at least one gene in the fowl plague virus genome by a corresponding human influenza virus gene resulted in the decrease of virulence for 1-day-old chickens. The presence of three P genes from human influenza virus genome in the genome of the recombinant proved to be insufficient for the capability of the recombinant to reproduce in organ cultures of human origin.
Bibliography:L
L73
ISSN:0001-723X
1336-2305