Effects of aflatoxin on the cellular immune system

Observations of aflatoxin induced thymic involution were followed by studies of other parameters of cellular immunity. Guinea pigs treated with 0.03 to 0.35 mg aflatoxin B1 for 3 to 5 weeks were tested for the development of cutaneous hypersensitivity, migration inhibition factor activity, and stimu...

Full description

Saved in:
Bibliographic Details
Published inAnnales de la nutrition et de l'alimentation Vol. 31; no. 4/6; pp. 781 - 897
Main Authors Pier, A.C, Fichtner, R.E, Cysewski, S.J
Format Journal Article
LanguageEnglish
Published France 1977
Subjects
Aflatoxins - pharmacology
Animals
Guinea Pigs
Immunity, Cellular
Lymphocyte Activation
Macrophage Migration-Inhibitory Factors - biosynthesis
Online AccessGet more information

Cover

More Information
Summary:Observations of aflatoxin induced thymic involution were followed by studies of other parameters of cellular immunity. Guinea pigs treated with 0.03 to 0.35 mg aflatoxin B1 for 3 to 5 weeks were tested for the development of cutaneous hypersensitivity, migration inhibition factor activity, and stimulation of lymphocyte transformation. A significant suppression of cutaneous hypersensitivity to a Nocardia asteroides sensitin in sensitized aflatoxin recipients was demonstrated. In vitro reductions in migration inhibition factor (MIF) and depressed stimulation indices (Phytohemagglutinin) of peripheral blood lymphocytes were also demonstrated in aflatoxin recipients but did not reach significant levels.
ISSN:0003-4037