A Comparison of the Anti-inflammatory Activity of Surfactin A, B, C, and D from Bacillus subtilis

• Published in: Journal of microbiology and biotechnology Vol. 16; no. 10; pp. 1656 - 1659
• Main Authors: Kim, S.D. (Kyungpook National University, Daegu, Republic of Korea), Cho, J.Y. (Kangwon National University, Chuncheon, Republic of Korea), Park, H.J. (Inje University, Gimhae, Republic of Korea), Lim, C.R. (Inje University, Gimhae, Republic of Korea), Lim, J.H. (Chungnam National University, Daejeon, Republic of Korea), Yun, H.I. (Chungnam National University, Daejeon, Republic of Korea), Park, S.C. (Kyungpook National University, Daegu, Republic of Korea), Kim, S.K. (Chungnam National University, Daejeon, Republic of Korea), Rhee, M.H. (Kyungpook National University, Daegu, Republic of Korea), E-mail: rheemh@knu.ac.kr
• Format: Journal Article
• Language: English
• Published: Seoul Korean Society for Applied Microbiology 01.10.2006; 한국미생물·생명공학회
• Subjects: anti-inflammatory activity; Biological and medical sciences; Biotechnology; Fundamental and applied biological sciences. Psychology; inducible nitric oxide synthase; NITRIC OXIDE; OXIDO NITRICO; OXYDE NITRIQUE; pro-inflammatory cytokines; Surfactin A, B, C, D; 생물학; B; C; D; Enzyme; Bacillus subtilis; Antiinflammatory agent; Cytokine; Surfactin A; Bacillaceae; Nitric-oxide synthase; anti-inflammatory activity; inducible nitric oxide synthase; Bacillales; Nitric oxide; pro-inflammatory cytokines; Bacteria; Oxidoreductases; Comparative study
• ISSN: 1017-7825

Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by 1 ㎍/ml of lipopolysaccharide (LPS) in murine RAW264.7 cells. In order to compare the anti-inflammatory effects of surfactin isoforms, we examined the inhibition of LPS-induced NO production and the pro-inflammatory cytokine expression level.