A Comparison of the Anti-inflammatory Activity of Surfactin A, B, C, and D from Bacillus subtilis
Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of...
Saved in:
Published in | Journal of microbiology and biotechnology Vol. 16; no. 10; pp. 1656 - 1659 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Seoul
Korean Society for Applied Microbiology
01.10.2006
한국미생물·생명공학회 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by 1 ㎍/ml of lipopolysaccharide (LPS) in murine RAW264.7 cells. In order to compare the anti-inflammatory effects of surfactin isoforms, we examined the inhibition of LPS-induced NO production and the pro-inflammatory cytokine expression level. |
---|---|
Bibliography: | 2007002809 A50 G704-000169.2006.16.10.010 |
ISSN: | 1017-7825 |