Cardiac glycoside poisoning in sheep caused by urginea physodes (Jacq.) Bak. and the isolated physodine A

Urginea physodes (Jacq.) Bak., a species closely related to or possibly synonymous with U. pusilla, is described and its distribution given. Four bufadienolides were isolated from U. physodes and the approximated LD50 and cumulative effect of some of them determined in guinea pigs. The most toxic on...

Full description

Saved in:
Bibliographic Details
Published inOnderstepoort journal of veterinary research Vol. 54; no. 4; pp. 641 - 644
Main Authors Nel, P.W, Schultz, R.A, Jordaan, P, Anderson, L.A.P, Kellerman, T.S, Reid, C
Format Journal Article
LanguageEnglish
Published South Africa 01.12.1987
Subjects
Animals
Bufanolides - poisoning
Cardiac Glycosides - poisoning
Drimia
glycosides
Guinea Pigs
isolation
Plant Poisoning - veterinary
Plants, Toxic - analysis
Plants, Toxic - anatomy & histology
poisoning
Sheep
Sheep Diseases - chemically induced
South Africa
toxicity
South Africa
Online AccessGet more information

Cover

More Information
Summary:Urginea physodes (Jacq.) Bak., a species closely related to or possibly synonymous with U. pusilla, is described and its distribution given. Four bufadienolides were isolated from U. physodes and the approximated LD50 and cumulative effect of some of them determined in guinea pigs. The most toxic one proved to be mildly cumulative. Typical signs of acute cardiac glycoside poisoning, involving the locomotory, gastro-intestinal, respiratory and cardiac system, were seen in the field cases and/or were experimentally induced by the plant. Similar signs could also be induced by injecting the isolated bufadienolide, physodine A, to a sheep.
ISSN:0030-2465
2219-0635