Quantitative evaluation of chlortoluran-induced splenic hemosiderosis by means of an image analyzer

This study investigated a technique for the quantification of hemosiderin layed down in the spleen. The model used was the rat to which the urea-based herbicide chlortoluran was fed for 90 days. There was good correlation between hematological, biochemical, histological and image analytical techniqu...

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Bibliographic Details
Published inVeterinary and human toxicology Vol. 31; no. 3; p. 218
Main Authors Nyska, A, Waner, T, Scolnik, M, Zuckerman, A, Pirak, M, Kuehnberg, W, Gordon, E B
Format Journal Article
LanguageEnglish
Published United States 01.06.1989
Subjects
Animals
bazo
Bilirubin - analysis
Body Weight - drug effects
diagnosis
diagnostic
diagnostico
haemolysis
hemolisis
hemolyse
Hemosiderosis - chemically induced
Hemosiderosis - diagnosis
Hemosiderosis - pathology
herbicidas
herbicide
herbicides
Herbicides - toxicity
Image Processing, Computer-Assisted
Organ Size - drug effects
Phenylurea Compounds - toxicity
rat
rata
rate
Rats
Rats, Inbred Strains
sex
sexe
sexo
spleen
Splenic Diseases - chemically induced
Splenic Diseases - diagnosis
Splenic Diseases - pathology
toxicidad
toxicite
toxicity
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Summary:This study investigated a technique for the quantification of hemosiderin layed down in the spleen. The model used was the rat to which the urea-based herbicide chlortoluran was fed for 90 days. There was good correlation between hematological, biochemical, histological and image analytical techniques when splenic hemosiderosis was of a moderate to severe degree. Where hemosiderosis was of a slight nature, only the technique of image analysis was able to detect the on-going changes.
Bibliography:H01
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ISSN:0145-6296