Fatal myocarditis in mice fed rancid purified feed

An outbreak of disease characterized by diarrhea, severe myocarditis, and high mortality occurred in a group of 800 male B6C3F1/ Har mice fed powdered purified diets. A total of 292 animals died. No evidence of an infectious agent was found, and the disease was reproduced in healthy mice by feeding...

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Bibliographic Details
Published inLaboratory animal science (Chicago) Vol. 34; no. 1; p. 70
Main Authors Kusewitt, D F, Wagner, J E, Dixon, L W, Anderson, P A
Format Journal Article
LanguageEnglish
Published United States 01.02.1984
Subjects
Animal Feed - analysis
Animal Feed - poisoning
Animals
Disease Outbreaks - veterinary
Lipid Peroxides - poisoning
Male
Mice
Mice, Inbred ICR
Mice, Inbred Strains
Myocarditis - epidemiology
Myocarditis - etiology
Myocarditis - veterinary
Rodent Diseases - epidemiology
Rodent Diseases - etiology
Rodent Diseases - pathology
Vitamin K Deficiency - veterinary
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Summary:An outbreak of disease characterized by diarrhea, severe myocarditis, and high mortality occurred in a group of 800 male B6C3F1/ Har mice fed powdered purified diets. A total of 292 animals died. No evidence of an infectious agent was found, and the disease was reproduced in healthy mice by feeding the purified diets, suggesting a nutritional deficiency or toxicity. Analysis of the feed revealed adequate levels of vitamin E, reduced levels of thiamine, and elevated levels of lipoperoxide. It was concluded that mortality was due to myocarditis associated with the ingestion of rancid feed.
Bibliography:L34
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ISSN:0023-6764