acute effects of corticotropin-releasing factor on energy expenditure in lean and obese women

Corticotropin-releasing factor (CRF) has been implicated in the development of obesity in genetically obese rodents. We have investigated the effect of 100 micrograms of intravenous CRF on energy expenditure in women, comparing the response in obese and lean volunteers. In response to CRF, energy ex...

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Bibliographic Details
Published inInternational journal of obesity Vol. 16; no. 7; pp. 529 - 534
Main Authors Chong, P.K.K, Jung, R.T, Bartlett, W.A, Browning, M.C.K
Format Journal Article
LanguageEnglish
Published England 01.07.1992
Subjects
Adrenocorticotropic Hormone - blood
Adult
animal experimentation
Calorimetry
corticotropin-releasing hormone
Corticotropin-Releasing Hormone - administration & dosage
Corticotropin-Releasing Hormone - pharmacology
energy expenditure
Energy Metabolism - drug effects
Female
Humans
Hydrocortisone - blood
Injections, Intravenous
lean body mass
Middle Aged
Norepinephrine - blood
obesity
Obesity - metabolism
sympathetic nervous system
women
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Summary:Corticotropin-releasing factor (CRF) has been implicated in the development of obesity in genetically obese rodents. We have investigated the effect of 100 micrograms of intravenous CRF on energy expenditure in women, comparing the response in obese and lean volunteers. In response to CRF, energy expenditure as measured by indirect calorimetry increased rapidly with a peak response in both groups reached by two minutes with a ten minute post-CRF response averaging 9.0% in the lean and 11.0% in the obese. Subsequently, energy expenditure remained elevated for a longer duration in the lean compared to the obese. Overall, the total 30 min cumulative metabolic rise was similar in the lean and obese. The increments in energy expenditure were associated with elevation of plasma noradrenaline levels, suggesting the possible involvement of the sympathetic nervous system. The adrenocorticotrophic (ACTH) and cortisol responses to CRF were similar in obese and lean. Intravenous administration of CRF therefore acutely increases energy expenditure in both lean and obese healthy subjects.
ISSN:0307-0565
1476-5497