Cardiopulmonary effects of butorphanol tartrate in dogs

The effects of butorphanol given (IV) at dose levels of 0.1 and 0.4 mg/kg were evaluated in conscious dogs, n = 5 for each dose. Mild sedation occurred, though it was greater in dogs given the larger dose. Two dogs in each group panted, but PaCO2 was not significantly changed. Small, but significant...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 44; no. 2; p. 329
Main Author Trim, C.M
Format Journal Article
LanguageEnglish
Published United States 01.02.1983
Subjects
Animals
Blood Pressure - drug effects
Butorphanol - analogs & derivatives
Butorphanol - pharmacology
Dogs - physiology
Female
Heart Rate - drug effects
Hemodynamics - drug effects
Male
Morphinans - pharmacology
Oxygen - blood
Partial Pressure
Respiration - drug effects
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Summary:The effects of butorphanol given (IV) at dose levels of 0.1 and 0.4 mg/kg were evaluated in conscious dogs, n = 5 for each dose. Mild sedation occurred, though it was greater in dogs given the larger dose. Two dogs in each group panted, but PaCO2 was not significantly changed. Small, but significant, decreases in arterial blood pressure, heart rate, and PaO2 occurred (P less than 0.05). Base excess developed a negative trend. The PCV and total protein decreased slightly in dogs given the smaller dose, but were unchanged with the larger dose. Plasma glucose remained within acceptable limits.
Bibliography:8255260
L70
ISSN:0002-9645
1943-5681