Effects of corticosteroids on responses of bovine peripheral blood lymphocytes cultured with phytohemagglutinin [Immunosuppressive drugs, dairy cattle]

Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that,...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 36; no. 8; p. 1243
Main Authors Muscoplat, C.C, Shope, R.E. Jr, Chen, A.W, Johnson, D.W
Format Journal Article
LanguageEnglish
Published United States 01.08.1975
Subjects
Animals
Cattle - blood
Dexamethasone - administration & dosage
Dexamethasone - pharmacology
Hydrocortisone - pharmacology
Injections, Intramuscular
Lectins - pharmacology
Lymphocyte Activation
Male
Thymidine - metabolism
Tritium
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Summary:Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that, in calves, short-term, high-dose immunosuppressive therapy with corticosteroids produces a population of lymphocytes resistant to corticosteroids, possibly by destruction of corticosteroid-sensitive lymphocytes.
Bibliography:L74
7505466
ISSN:0002-9645
1943-5681