Normal hematology, serology, and serum protein electrophoresis values in fetal Yucatan miniature swine

We are currently developing fetal models of congenital heart disease in Yucatan miniature swine for pharmacologic, diagnostic, and interventional methods used to treat cardiac arrhythmias and ventricular septal defect. Fifty-four fetuses from 12 pregnant sows were included in this study. Eleven were...

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Published inLaboratory animal science (Chicago) Vol. 45; no. 3; p. 285
Main Authors Dungan, L.J. (Medical University of South Carolina, Charleston, SC.), Wiest, D.B, Fyfe, D.A, Smith, A.C, Swindle, M.M
Format Journal Article
LanguageEnglish
Published United States 01.06.1995
Subjects
Animals
Blood Cell Count - veterinary
Blood Chemical Analysis - veterinary
Blood Protein Electrophoresis
CARDIOPATHIE
CERDO
COMPOSICION DE LA SANGRE
COMPOSITION DU SANG
Databases, Factual
Disease Models, Animal
ELECTROLITOS
ELECTROLYTE
Electrolytes - blood
Electrophoresis, Cellulose Acetate
ENANO
ENFERMEDADES CARDIACAS
Enzymes - blood
Female
Fetal Blood - chemistry
FETO
Fetus - chemistry
FOETUS
Gestational Age
IMMUNOLOGIE
INMUNOLOGIA
Male
METABOLITE
METABOLITOS
MODELE ANIMAL
MODELOS ANIMALES
NAIN
PORCIN
Pregnancy
PROTEINAS SANGUINEAS
PROTEINE SANGUINE
Reference Values
Swine
Swine, Miniature - blood
Swine, Miniature - embryology
TRASTORNOS GENETICOS
TROUBLE GENETIQUE
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Summary:We are currently developing fetal models of congenital heart disease in Yucatan miniature swine for pharmacologic, diagnostic, and interventional methods used to treat cardiac arrhythmias and ventricular septal defect. Fifty-four fetuses from 12 pregnant sows were included in this study. Eleven were fetuses between 76 and 88 days of gestation (early gestation fetuses). A second population of 43 fetuses were between 96 and 110 days of gestation (late gestation fetuses). Erythrocyte, leukocyte, serum electrolyte, enzyme, lipid, carbohydrate, and metabolite values were measured. Complete serum protein profiles were also obtained by electrophoresis. Significant differences could be shown between the sows and fetuses and between the early and late gestation fetuses in all of the categories studied, though not for every parameter. This study provides a large normal database for development of Yucatan miniature swine as an animal model in the rapidly expanding field of fetal medicine
Bibliography:T10
L01
9625601
L50
ISSN:0023-6764