Biosynthetic pathway of citrinin in the filamentous fungus Monascus ruber as revealed by 13C nuclear magnetic resonance

Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and ci...

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Published inApplied and Environmental Microbiology Vol. 65; no. 1; pp. 311 - 314
Main Authors Watson, A.J, Klaebe, A, Loret, M.O, Goma, G, Blanc, P.J, Francois, J
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 1999
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fungi
Microbiology
Mycology
NMR
Nuclear magnetic resonance
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
plant biochemistry
plant physiology
Fungi
Toxin
Isotope labelling
Mycotoxin
Pigments
Citrinin
Biosynthesis
NMR spectrometry
Metabolic pathway
Thallophyta
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Summary:Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point.
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Corresponding author. Mailing address: Centre Bioingénierie Gilbert Durand, CNRS UMR 5504, LA INRA, Institut National des Sciences Appliquées de Toulouse, Complexe Scientifique de Rangueil, 31077 Toulouse, France. Phone: 33 5 61 55 94 92. Fax: 33 5 61 55 94 00. E-mail: fran_jm@insa-tlse.fr.
ISSN:0099-2240
1098-5336