Structure and Expression of OsMRE11 in Rice

• Published in: Journal of plant biology = Singmul Hakhoe chi Vol. 48; no. 2; pp. 229 - 236
• Main Authors: Hong, J.P. (Yonsei University, Seoul, Republic of Korea), Kim, S.M. (Yonsei University, Seoul, Republic of Korea), Ryu, M.Y. (Yonsei University, Seoul, Republic of Korea), Choe, S.H. (Seoul National University, Seoul, Republic of Korea), Park, P.B. (The University of Suwon, Suwon, Republic of Korea), An, G.H. (Pohang University of Science and Technology, Pohang, Republic of Korea), Kim, W.T. (Yonsei University, Seoul, Republic of Korea), E-mail: wtkim@yonsei.ac.kr
• Format: Journal Article
• Language: English
• Published: 한국식물학회 30.06.2005
• Subjects: DNA repair; genome stability; genotoxic agents; Mre11; ORYZA SATIVA; 생물학
• ISSN: 1226-9239; 1867-0725
• DOI: 10.1007/BF03030412

In yeast and human cells, the Mre11 complex, which consists of Mre11, Rad50, and Xrs2/Nbs1 proteins, participates in basic aspects of chromosome metabolism, such as the repair of meiotic DNA breaks and telomere maintenance. In this study, we isolated a full-length cDNA clone, pOsMre11, encoding a rice ortholog of the Mre11 protein. Its predicted protein sequence (M∧r = 79.2 kDa and pI value = 5.91) contains a metallo-phosphoesterase domain at its N-terminal region, and a single putative DNA binding domain in the central region of the protein, with significant homology to corresponding motifs in human and yeast Mre11 proteins.