Vasodilating effect of the root bark extract of Ficus saussureana on guinea pig aorta

The effect of the aqueous extract of the root bark of Ficus saussureana DC. (Moraceae) on KCl- and noradrenaline-induced contractions of guinea pig aortic strips was studied. The extract produced a dose-dependent relaxation of 30 mM KCl induced contraction of the aortic strips. In contrast, no signi...

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Bibliographic Details
Published inPharmaceutical biology Vol. 41; no. 5; pp. 371 - 374
Main Authors DONGMO, A. B, NDOM, J. C, MASSOMA, L. D, DZIKOUK, D. G, FOMANI, M, BISSOUE, Nouga, KAMANYI, A, VIERLING, W
Format Journal Article
LanguageEnglish
Published Lisse Swets & Zeitlinger 01.08.2003
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Root
Pharmacognosy
Rodentia
Bark
Smooth muscle
Moraceae
Muscle contraction
In vitro
Artery
Biological activity
Vasodilation
Medicinal plant
Vertebrata
Mammalia
Guinea pig
Ficus
Dicotyledones
Blood vessel
Animal
Angiospermae
Plant origin
Aorta
Spermatophyta
Circulatory system
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Summary:The effect of the aqueous extract of the root bark of Ficus saussureana DC. (Moraceae) on KCl- and noradrenaline-induced contractions of guinea pig aortic strips was studied. The extract produced a dose-dependent relaxation of 30 mM KCl induced contraction of the aortic strips. In contrast, no significant relaxant effect was seen with noradrenaline-induced contractions. The inhibition of contractions was most significant: 62.47+/-3.79% and 20.78+/-3.97%, at the doses 100 and 300 mug/ml, respectively. The results suggest that the relaxation effect of the extract may be due to the blockade of the influx of extracellular Ca2+ through voltage-operated channels into the cell.
ISSN:1388-0209
1744-5116