Large-Scale Fermentation for the Production of Teicoplanin From a Mutant of Actinoplanes teichomyceticus

Mutation and its pilot-scale fermentation were conducted for the production of teicoplanin from Actinoplanes teichomyceticus. The fermentation medium was optimized by replacement and Plackett-Burman experimental design. A maximum production of 1,500 mg/l teicoplanin was obtained by pilot-scale ferme...

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Bibliographic Details
Published inJournal of microbiology and biotechnology Vol. 15; no. 4; pp. 787 - 791
Main Authors Lee, J.C. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Min, J.W. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Park, D.J. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Son, K.H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Yoon, K.H. (Woosong University, Daejeon, Republic of Korea), Park, H.R. (Kyungnam University, Masan, Republic of Korea), Park, Y.S. (Kunwha Pharmaceutical Co., Kongju, Republic of Korea), Kwon, M.G. (Kunwha Pharmaceutical Co., Kongju, Republic of Korea), Lee, J.M. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Kim, C.J. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), E-mail: changjin@kribb.re.kr
Format Journal Article
LanguageEnglish
Published Seoul Korean Society for Applied Microbiology 01.08.2005
Subjects
Actinoplanes teichomyceticus
Biological and medical sciences
Biotechnology
FERMENTACION
FERMENTATION
Fundamental and applied biological sciences. Psychology
MUTACION
MUTATION
teicoplanin
Actinomycetales
Mutagenesis
Actinoplanes
Production
Bacteria
Actinoplanes teichomyceticus
Actinomycetes
Large scale
Mutation
Actinoplanaceae
Fermentation
Teicoplanin
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Summary:Mutation and its pilot-scale fermentation were conducted for the production of teicoplanin from Actinoplanes teichomyceticus. The fermentation medium was optimized by replacement and Plackett-Burman experimental design. A maximum production of 1,500 mg/l teicoplanin was obtained by pilot-scale fermentation in an optimized medium containing (g/l): 30 g maltodextrin, 5 g glucose, 5 g yeast extract, 5 g soybean meal, 0.5 g MgSO₄ㆍ7H₂O, 0.1 g NaCl, 0.1 g CaCl₂ㆍ2H₂O, and 50 g Diaion HP-20.
Bibliography:T10
2006015262
ISSN:1017-7825