Antimicrobial Activity of Hetero-Chitosans and Their Oligosaccharides with Different Molecular Weights

• Published in: Journal of microbiology and biotechnology Vol. 14; no. 2; pp. 317 - 323
• Main Authors: Park, P.J. (Pukyong National University, Busan, Republic of Korea), Je, J.Y. (Pukyong National University, Busan, Republic of Korea), Byun, H.G. (Pukyong National University, Busan, Republic of Korea), Moon, S.H. (Pukyong National University, Busan, Republic of Korea), Kim, S.K. (Pukyong National University, Busan, Republic of Korea), E-mail: sknkim@mail.pknu.ac.kr
• Format: Journal Article
• Language: English
• Published: Seoul Korean Society for Applied Microbiology 01.04.2004
• Subjects: antimicrobial activity; Biological and medical sciences; Biotechnology; chitooligosaccharide; CHITOSAN; CHITOSANE; Fundamental and applied biological sciences. Psychology; Hetero-chitosan; minimum inhibitory concentration; QUITOSANO; Hetero-chitosan; Oligosaccharide; chitooligosaccharide; Chitosan; Concentration; Inhibition; antimicrobial activity; Molecular mass; Antimicrobial agent; minimum inhibitory concentration
• ISSN: 1017-7825

This study was performed to investigate the antimicrobial effects of hetero-chitosans and their oligosaccharides against three Gram-negative bacteria and five Gram-positive bacteria. Nine classes of hetero-chitosan oligosaccharides consisted of partially deacetylated chitosans; 90%, 75%, and 50% deacetylated chitosans. Based on molecular weight, they were prepared using an ultrafiltration membrane reactor system. Seventy-five percent deacetylated chitosan showed the highest antimicrobial acitivity as compared with the 90% and 50% deacetylated chitosan, and the activity was dependent on their molecular weights.