The formation and enzymatic repair of DNA modifications caused by haloethylnitrosoureas and related compounds

The haloethylnitrosoureas are both useful antitumor agents and known carcinogens. These biological activities are believed to be associated with DNA modification, and some biologically significant lesions have been identified in DNA exposed to these agents. At the same time, DNA repair is a cause of...

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Bibliographic Details
Published inNucleic acids symposium series (1979) no. 27; pp. 25 - 26
Main Authors Ludlum, D, Habraken, Yvette, Carter, C, Matijasevic, Z
Format Journal Article Web Resource
LanguageEnglish
Published England Oxford University Press 1992
Subjects
Animals
Biochemistry
Biochemistry, biophysics & molecular biology
Biochimie, biophysique & biologie moléculaire
biophysics
Cattle
DNA - drug effects
DNA - genetics
DNA Repair
Ethylnitrosourea - analogs & derivatives
Ethylnitrosourea - toxicity
Halogens - chemistry
Halogens - toxicity
Life sciences
molecular biology
Sciences du vivant
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Summary:The haloethylnitrosoureas are both useful antitumor agents and known carcinogens. These biological activities are believed to be associated with DNA modification, and some biologically significant lesions have been identified in DNA exposed to these agents. At the same time, DNA repair is a cause of resistance to treatment by these agents, and may also serve as protection against their carcinogenic effects.
Bibliography:scopus-id:2-s2.0-0027018037
ISSN:0261-3166
1746-8272
1746-8272