Toxicopathological changes of ciprofloxacin in broiler chickens

Toxicopathological changes of graded dose levels of ciprofloxacin, a second generation of quinolone chemotherapeutic agent, were determined in broiler chickens. Birds orally administered with therapeutic does (5mg kg(-1) b/wt.) developed mild gastrointestinal signs, anaemia, leucopoenia, hyproglycem...

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Bibliographic Details
Published inIndian journal of animal sciences Vol. 73; no. 1
Main Authors Niyogi, D, Bhowmik, M.K. (West Bengal University of Animal and Fishery Sciences, Kolkata (India))
Format Journal Article
LanguageEnglish
Published 01.01.2003
Subjects
bactericides
bacterioses
broiler chickens
dosage
mycoplasmoses
toxicology
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Summary:Toxicopathological changes of graded dose levels of ciprofloxacin, a second generation of quinolone chemotherapeutic agent, were determined in broiler chickens. Birds orally administered with therapeutic does (5mg kg(-1) b/wt.) developed mild gastrointestinal signs, anaemia, leucopoenia, hyproglycemia, hypoproteinemia, increased transaminase activity and low degree of toxic hepatitis and nephrosis. Double and triple therapeutic doses produced severe gastrointextinal signs, partial loss of body weight and leg weakness accompanied with significant (P0.01) anaemia, leucopoenia, hypoglycemia, hypoproteinemia and increased transaminase activity. Pathological lesions comprised massive toxic hepatitis, necrotic enteritis and toxic nephrosis and/or nephritis in birds. Triple therapeutic dose also had cytotoxic effect on antibody producing cells of bursa and toxic arthropathy.
Bibliography:L70
L73
2005000185
ISSN:0367-8318