Formation of inclusion complexes of cyclodextrin with ethanol under anhydrous conditions

Complex formation of poorly water soluble organic compounds with cyclodextrin (CD) is quite difficult in an aqueous cyclodextrin system. Formation of the inclusion complex of d-limonene, phenyl ethanol, acetophenone, or menthol was investigated in a slurry form of alpha-, beta-, or gamma-CD in organ...

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Published inBioscience, biotechnology, and biochemistry Vol. 62; no. 11
Main Authors Yoshii, H. (Tottori Univ. (Japan)), Kometani, T, Furuta, T, Watanabe, Y, Linko, Y.Y, Linko, P
Format Journal Article
LanguageEnglish
Published 01.11.1998
Subjects
ADDITIF
ADDITIVES
ADITIVOS
CHEMICAL SYNTHESIS
DEXTRINAS
DEXTRINE
DEXTRINS
ETANOL
ETHANOL
METHODE
METHODS
METODOS
SINTESIS QUIMICA
SOLVANT
SOLVENTES
SOLVENTS
SYNTHESE CHIMIQUE
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Summary:Complex formation of poorly water soluble organic compounds with cyclodextrin (CD) is quite difficult in an aqueous cyclodextrin system. Formation of the inclusion complex of d-limonene, phenyl ethanol, acetophenone, or menthol was investigated in a slurry form of alpha-, beta-, or gamma-CD in organic solvents or alcohol under anhydrous conditions. Ethanol and methanol were found to be good solvents for this method. The use of ethanol as the solvent was investigated in greater detail. There existed an optimal amount of ethanol for the maximum inclusion of d-limonene as the guest compound. However, an excess of ethanol inhibited the inclusion. An adsorption model of alcohol on CD, analogous to the substrate inhibition model of enzyme kinetics, could correlate the inclusion ratio with the amount of alcohol added to CD
Bibliography:1999006332
U30
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.2166