In vitro effect of combinations of antimicrobial agents and EDTA-tromethamine on certain gram-positive bacteria

Combinations of EDTA-tromethamine and 7 antimicrobial agents (chloramphenicol, nalidixic acid, oxytetracycline, penicillin, polymyxin-B, streptomycin, and a triple sulfonamide preparation) were tested for synergistic activities against Staphylococcus aureus, Corynebacterium renal, Listeria monocytog...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 44; no. 11; p. 2167
Main Authors Wooley, R.E, Jones, M.S, Gilbert, J.P, Shotts, E.B. Jr
Format Journal Article
LanguageEnglish
Published United States 01.11.1983
Subjects
Anti-Bacterial Agents - pharmacology
Drug Combinations
Drug Resistance, Microbial
Drug Synergism
Edetic Acid - administration & dosage
Edetic Acid - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Tromethamine - administration & dosage
Tromethamine - pharmacology
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Summary:Combinations of EDTA-tromethamine and 7 antimicrobial agents (chloramphenicol, nalidixic acid, oxytetracycline, penicillin, polymyxin-B, streptomycin, and a triple sulfonamide preparation) were tested for synergistic activities against Staphylococcus aureus, Corynebacterium renal, Listeria monocytogenes, Erysipelothrix rhusiopathiae, and a beta-hemolytic streptococci. Two in vitro tests were used--minimal inhibitory concentrations of the drugs and a 2-dimensional Microtiter checkerboard technique. A slight synergistic action was seen when L monocytogenes was exposed to combinations of penicillin-EDTA or streptomycin-EDTA.
Bibliography:L73
8299937
ISSN:0002-9645
1943-5681