Serum erythromycin concentration in sheep fed two diets

Serum erythromycin concentrations following a single IV injection (12.5 mg/kg) were compared in 6 sheep during feeding of a grass hay diet and a concentrate diet. The concentrate diet resulted in a mean decrease of at least 1 pH unit in forestomach fluid, but did not significantly alter either the s...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 45; no. 6; p. 1148
Main Authors Wilson, R.C, Huber, T.L, Goetsch, D.D
Format Journal Article
LanguageEnglish
Published United States 01.06.1984
Subjects
Animal Feed
Animals
Erythromycin - administration & dosage
Erythromycin - blood
Female
Half-Life
Hydrogen-Ion Concentration
Male
Sheep - blood
Stomach, Ruminant - metabolism
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Summary:Serum erythromycin concentrations following a single IV injection (12.5 mg/kg) were compared in 6 sheep during feeding of a grass hay diet and a concentrate diet. The concentrate diet resulted in a mean decrease of at least 1 pH unit in forestomach fluid, but did not significantly alter either the serum drug concentrations or half-life. Variable antibacterial activity was present in forestomach fluid as early as 1 or 2 hours after injection. This study indicates that ion-trapping in forestomach fluid as a result of normal dietary changes does not require therapeutic dosage adjustment.
Bibliography:L30
8502647
L50
L36
ISSN:0002-9645
1943-5681